A new study in April 2, 2013 issue of the journal Annals of Internal Medicine shows that 17% of patients taking statins discontinued the medicine because of side effects. This is almost twice the number of people stopping statins in the clinical trials. The study emphasized that almost half of these people could go back on statins, a different one or a lower dose of the same one, without recurrence of side effect.
The point I noticed was that in practice the number of side effects of drugs is far more than in clinical trials. We saw that about the ACE inhibitors. The incidence of cough was reported to be 0.7% in the FDA approved label for Zestril in 1993. Later on studies of patients in clinical practice showed that the incidence of cough was 10%!